O le a le Shikimic Acid?

Shikimic acid (3,4,5-trihydroxy-1-cyclohexene-1-carboxylic acid) o se mea faʻapitoa faʻapitoa faʻapitoa lea e taua tele i le biosynthesis o le lignin, mea manogi amino acids (phenylalanine, tyrosine ma tryptophan), ma le tele. laau ma microbial alkaloids.

O le Shikimic acid e masani ona fa'aaogaina e fai ma mea amata mo le gaosiga o fale gaosi oloa o le antiviral drug oseltamivir (o se vaila'au fa'ama'i fa'ama'i fa'ama'i H5N1 e fa'aaogaina e togafitia ma puipuia ai fa'ama'i uma o le fulū). O le tu'ufa'atasiga o le (-)-zeylenone e fa'avae i luga ole Shikimic Acid ua lipotia mai e fa'aaogaina lautele e fai ma sui mo le kanesa chemotherapy. O loʻo maua faʻamatalaga i luga o le tuʻufaʻatasiga o le monopalmitoyloxy Shikimic Acid, o loʻo i ai le anticoagulant gaioiga ma e mafai ona faʻaititia le toto toto pe a tuʻuina i totonu. O se vaega su'esu'e a Saina na fa'apipi'iina se mea e maua mai ai le Shikimic Acid, triacetyl Shikimic Acid, lea e fa'aalia ai le anticoagulant ma le antithrombotic.

E le gata i lea, o le Shikimic Acid derivatives ua faʻaalia le fiafia tele i faʻatoʻaga ona o le tele o ia mea o loʻo faʻaaogaina e avea ma vailaʻau ma vailaʻau faʻamaʻi ona e mafai ona latou poloka le auala Shikimic Acid i laau ma siama e aunoa ma le afaina ai o mamame.

O le mea lea, e mafai ona faʻaaogaina le Shikimic Acid e avea o se mea faʻafefe mo le tuʻufaʻatasia o meaola i faʻataʻitaʻiga faʻasaienisi ma faʻafomaʻi i le kemisi ma vailaʻau, aemaise lava mo le sauniuniga o vailaʻau eseese.

I le avea ai o se vailaʻau vailaʻau taua, shikimic acid e mafai ona faʻaaogaina i togafitiga o le tele o faʻamaʻi:

1. Antibacterial ma antitumor

I le 1987, na iloa ai e le au atamamai Iapani o le analog o le glyoxalase I inhibitor synthesized e le methyl anthranilate o loʻo i ai se aafiaga faʻaalia i luga o le laina telefoni Hela ma Escheri ascites carcinoma, e mafai ona faʻaumiina le taimi o le ola o isumu faʻamaʻi i le leukemia cell L1210, ma o le toxicity e fai si maualalo, o lona aafiaga fa'alavelave e tele lava ina feso'ota'i ma le sulfur hydride reaction. 1988, ua maua e le au atamamai Saina I le 1988, ua tuufaatasia e le au atamamai Saina se mea e maua mai i le shikimic acid ma faamaonia ai o lenei tuufaatasiga ei ai le aafiaga o le taofia o sela leukemia L1210 in vitro.

2. Anti-thrombosis

O le aʻafiaga o le shikimic acid ma ana mea e maua i le cardiovascular system o loʻo faʻaalia i le matafaioi o le anti-thrombosis ma le faʻasaina o le faʻapipiʻiina o platelet. O su'esu'ega o lo'o fa'aalia ai: o le shikimic acid e iai sona a'afiaga malosi i le fa'aputuga o platelet o le adenosine diphosphate-fa'aoso i le ogatotonu o le alatoto embolism fa'ata'ita'iga o isumu; tui i totonu ma intramuscular o le shikimic acid e mafai ona faaumiumi ai le toto clotting taimi o isumu.

3. Anti-cerebral ischemia

O le Shikimic acid ma ona mea e maua ai le aʻafiaga o le faʻaleleia o le cerebral ischemia, aemaise lava i le faʻaitiitia o le tele o le cerebral infarction i le maeʻa ai o le ischemia cerebral i isumu, faʻaitiitia le sikoa o le neurological, faʻaitiitia le tikeri o le edema cerebral, faʻateleina le toto cerebral i le vaega ischemic. ma isi fa'ailoga. O nisi suʻesuʻega ua faʻaalia ai o ana mea e mafai ona faʻaititia ai le maualuga o le erythrocyte aggregation ma faʻalavelaveina platelet aggregation pe a uma le cerebral ischemia, ma faʻafaigofie ai le microcirculation cerebral.